Anticoagulants: An Essential Class of Drugs for Thrombotic Disorders

Anticoagulant discovered and remains an important choice for parenteral (injected) administration. It acts by accelerating the effect of antithrombin, a natural clotting inhibitor in blood. When heparin binds to antithrombin, it causes a conformational change that greatly increases the inhibitory activity of antithrombin against clotting factors such as thrombin and factor Xa. Heparin's effect is rapid in onset but also easily reversible by agents like protamine sulfate.

Anticoagulants, also known as blood thinners, are a class of medications that prevent the clotting of blood and the formation of blood clots. They do this by interfering with the body's normal clotting process or by inhibiting the action of certain clotting factors. Anticoagulants play an important role in treating and preventing various thrombotic conditions like deep vein thrombosis (DVT), pulmonary embolism (PE), atrial fibrillation, angina, heart attack and strokes.

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